师资队伍

  • 两院院士
  • 高层次人才
  • 在职教师
  • 荣休教师

王春江

办公地点:化北N309

联系电话:

电子邮箱:cjwang@whu.edu.cn

团队主页: http://wanglab.whu.edu.cn/

个人简介

新葡的京集团35222vip教授,博士生导师。2010年获得教育部新世纪优秀人才支持计划;2013年获聘新葡的京集团35222vip珞珈特聘教授;2013年年获得湖北省杰出青年基金资助;2013年获得Thieme Chemistry Journals Award;2015年获得国家杰出青年基金资助;2016年获得中国化学会青年手性化学奖。


教育经历

1997.09-2000.08     中南大学化学化工学院应用化学专业    硕士研究生

2000.09-2003.07     中国科学院上海有机化学研究所金属有机化学国家重点实验室   博士研究生


工作经历

2003.09-2006.07    美国宾州州立大学化学系,博士后研究

2006.07-2008.11    新葡的京集团35222vip,副教授,博士生导师

2008.11-至今         新葡的京集团35222vip,教授,博士生导师

 

研究方向

1. 高效、高立体选择性环加成反应(1,3-偶极环加成、Diels-Alder环加成反应等);

2. 具有生理活性的手性药物关键中间体、手性α-氨基酸(α-AAs) 的绿色高效构建;

3. 双功能有机小分子催化剂设计、合成及在不对称合成中的应用


代表成果

1. Chang, X.; Cheng, X.; Liu, X. T.; Fu, C.; Wang, W. Y.; Wang, C. J., Stereodivergent Construction of 1,4-Nonadjacent Stereocenters via Hydroalkylation of Racemic Allylic Alcohols Enabled by Copper/Ruthenium Relay Catalysis. Angew. Chem. Int. Ed. 2022, 61, e202206517.

2.  Xiao, L.; Chang, X.; Xu, H.; Xiong, Q.; Dang, Y.; Wang, C. J., Cooperative Catalyst-Enabled Regio- and Stereodivergent Synthesis of alpha-Quaternary alpha-Amino Acids via Asymmetric Allylic Alkylation of Aldimine Esters with Racemic Allylic Alcohols. Angew. Chem. Int. Ed. 2022, 61, e202212948.

3. Yi, Z. Y.; Xiao, L.; Chang, X.; Dong, X. Q.; Wang, C. J., Iridium-Catalyzed Asymmetric Cascade Allylation/Retro-Claisen Reaction. J. Am. Chem. Soc. 2022, 144, 20025-20034.

4. Xiao, L.; Wei, L.; Wang, C. J., Stereodivergent Synthesis of Enantioenriched gamma-Butyrolactones Bearing Two Vicinal Stereocenters Enabled by Synergistic Copper and Iridium Catalysis. Angew. Chem. Int. Ed. 2021, 60, 24930-24940.

5. Che, C.; Li, Y.-N.; Cheng, X.; Lu, Y.-N.; Wang, C.-J., Visible-Light-Enabled Enantioconvergent Synthesis of α-Amino Acid Derivatives via Synergistic Brønsted Acid/Photoredox Catalysis. Angew. Chem. Int. Ed. 2021, 60, 4698-4704.

6. Chang, X.; Yang, Y.; Shen, C.; Xue, K.-S.; Wang, Z.-F.; Cong, H.; Tao, H.-Y.; Chung, L. W.; Wang, C.-J., β-Substituted Alkenyl Heteroarenes as Dipolarophiles in the Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides Empowered by a Dual Activation Strategy: Stereoselectivity and Mechanistic Insight. J. Am. Chem. Soc. 2021, 143, 3519-3535.

7. Wei, L.; Chang, X.; Wang, C.-J., Catalytic Asymmetric Reactions with N-Metallated Azomethine Ylides. Acc. Chem. Res. 2020, 53, 1084-1100.

8.  Xu, S.-M.; Wei, L.; Shen, C.; Xiao, L.; Tao, H.-Y.; Wang, C.-J., Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction. Nat. Commun. 2019, 10, 5553.

9. Wei, L.; Zhu, Q.; Xiao, L.; Tao, H.-Y.; Wang, C.-J., Synergistic catalysis for cascade allylation and 2-aza-cope rearrangement of azomethine ylides. Nat. Commun. 2019, 10, 1594.

10. Wei, L.; Zhu, Q.; Xu, S.-M.; Chang, X.; Wang, C.-J., Stereodivergent synthesis of α,α-disubstituted α-amino acids via synergistic Cu/Ir catalysis. J. Am. Chem. Soc. 2018, 140, 1508-1513.

11. Wei, L.; Xu, S.-M.; Zhu, Q.; Che, C.; Wang, C.-J., Synergistic Cu/Pd catalysis for enantioselective allylic alkylation of aldimine esters: Access to α,α-disubstituted α-amino acids. Angew. Chem., Int. Ed. 2017, 56, 12312-12316.


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