师资队伍

  • 两院院士
  • 高层次人才
  • 在职教师
  • 荣休教师

许小娟

办公地点:化东-415

联系电话:

电子邮箱:xuxj@whu.edu.cn

团队主页:

个人简介

新葡的京集团35222vip教授,博士生导师;2012年入选武汉市“黄鹤英才计划”;2013年入选“教育部新世纪优秀人才计划”;2015年获聘新葡的京集团35222vip珞珈特聘教授;2022年获聘新葡的京集团35222vip-中南医院交叉研究院特聘教授。已发表学术论文110余篇,获授权发明专利3项;获2005年湖北省自然科学一等奖1项(排名第2)、教育部2012年度“高等学校十大科技进展”1项(排名第3)。”现担任Bioactive Carbohydrates and Dietary Fibre期刊编委 (2015-现在)。近5年主持国家自然科学基金3项、国家重点研发计划子课题1项。


教育经历

1997年6月,毕业于新葡的京集团35222vip化学系获理学学士学位

2000年5月,赴日本大阪大学从事高分子溶液理论研究一年

2002年6月,毕业于新葡的京集团35222vip获理学博士学位


工作经历

2001年7月,入职于新葡的京集团35222vip从事高分子教学和科研

2008年10月,获日本学术振兴学会(JSPS)资助赴神户大学从事多糖的结构-活性相关性研究二年


研究方向

天然高分子

1、多糖的多尺度结构、溶液性质及品质功能

2、多糖基微纳米材料

3、多糖的生物活性、构效关系及作用机制


代表成果

1. Liqin Cai†, Shujun Zhou†, Xiaojuan Xu*, Yanfeng Wang*, Zongwei Cai*, Lina Zhang. The composites of triple-helix glucan nanotubes/selenium nanoparticles target hepatocellular carcinoma to enhance ferroptosis by depleting glutathione and augmenting redox imbalance. Chem. Eng. J. 2022, 446(3): 137110.

2. Liqin Cai, Lina Zhang, Xiaojuan Xu*. One-step synthesis of ultra-small silver nanoparticles-loaded triple-helix β-glucan nanocomposite for highly catalytic hydrogenation of 4-nitrophenol and dyes. Chem. Eng. J. 2022, 442(1): 136114.

3. Huanhuan Chen#, Ying Sun#, Xiaojuan Xu*, Qifa Ye*. Targeted delivery of methotrexate by modified yeast β-glucan nanoparticles for rheumatoid arthritis therapy. Carbohydr. Polym. 2022, 284: 119183.

4. Bingchao Duan, Ying Sun, Siwei Zou, Xiaojuan Xu*. Fabrication of tumor-targeting composites based on the triple helical a-glucan through conjugation of aptamer. Carbohydr. Polym. 2021, 254: 117476.

5. Ying Sun, Bingchao Duan, Huanhuan Chen, Xiaojuan Xu*. A novel strategy for treating inflammatory bowel disease by targeting delivery of methotrexate through glucan particles. Adv. Healthcare Mater. 2020, 9 (6): 1901805.

6. Siwei Zou, Bingchao Duan, Xiaojuan Xu*. Inhibition of tumor growth by b-glucans through promoting CD4+ T cell immunomodulation and neutrophil-killing in mice. Carbohydr. Polym. 2019, 213: 370-381. 25.

7. Bingchao Duan#, Mengxia Li#, Ying Sun, Siwei Zou, Xiaojuan Xu*. Orally delivered antisense oligodeoxyribonucleotides of TNF-a via polysaccharide-based nanocomposites targeting intestinal inflammation. Adv. Healthcare Mater. 2019, 8(5): 1801389.

8. Bingchao Duan, Ying Sun, Siwei Zou, Xiaojuan Xu*. Nanoplatform constructed from a β-glucan and polydeoxyadenylic acid for cancer chemotherapy and imaging. Biomacromolecules 2019, 20 (4): 1567–1577.

9. Yan Meng, Xiaodan Shi, Liqin Cai, Sihai Zhang, Kan Ding, Shaoping Nie, Chuanfu Luo*, Xiaojuan Xu*, Lina Zhang*. Triple helix conformation of a polysaccharide determined with light scattering, AFM and molecular dynamic simulation. Macromolecules 2018, 51 (24): 10150

10. Zhaohua Ping, Ting Liu, Hui Xu, Yan Meng, Wenhua Li, Xiaojuan Xu*, Lina Zhang*. Construction of highly stable selenium nanoparticles embedded in hollow nanofibers of polysaccharide and their antitumor activities. Nano Res. 2017, 10: 3775–3789.


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